Endocrine Abstracts

Introduction: Dabigatran is a direct thrombin inhibitor which is used for reducing the risk of stroke or systemic embolism in patients with atrial fibrillation. Although INR monitoring is not required in the course of treatment, it may be complicated with spontaneous systemic bleeding. Sheehan’s syndrome is characterized with panhypopituitarism which is caused by necrosis of the pituitary gland. Recent studies have demonstrated that panhypopituitarism is associated with b...

Indroduction: Graves’ and Hashimoto’s thyroiditis are the most common autoimmune thyroid diseases. After Graves’, hypothyroidism can develop spontaneously or as a result of medical treatment, radioactive iodine therapy or surgery. Development of Graves’ after Hashimoto’s thyroiditis is a rare condition. Alopecia areata (AA) is an autoimmune disease. It has association with other autoimmune diseases such as thyroid disorders, anemias and other skin diso...

Introduction: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), stroke and cerebrovascular disease (CVD) are identified as risk factors for hypopituitarism. However, the mechanisms and the risk factors for the hypothalamo-pituitary dysfunction due to TBI, SAH, stroke and CVD are still unclear (1,2,3). Hypoxia, hypoxemia, neuroinflammation, autoimmunity could have impact in the pathogenesis (4). In patients with serious ventricular arrhythmias who need resuscitation,...

Fine needle aspiration biopsy is the cornerstone for cytologic evaluation of thyroid nodules. Thyroid nodule prevelance increases with age, however there is no cytologic study exclusively from geriatric patients.We examined the thyroid fine needle biopsy records taken from patients age 65 years or older between January 2006 and June 2009 at Dokuz Eylul University Hospital; and reviewed the cytological results of this group.We analy...

Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.Design: Prospective case-control study.Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.Meas...

Background: Idiopatic hypogonadotropic hypogonadism is a congenital abnormality due to GnRH deficiency which is associated with severe osteoporosis. Testosterone replacement has been shown to improve the loss in the bone mass. The aim of the present retrospective analysis was to measure the effect of human chorionic gonadotropin treatment on the improvement of bone mineral density.Methods: A total number of 96 young male (mean age 21±3.7 years) pati...

Objective: Ultrasound (US) guided percutaneous laser ablation (PLA) is a new procedure utilized to decrease nodule volume in symptomatic thyroid nodules, to provide euthyroidism in autonomous hyperfunctioning thyroid nodules, and to decrease compressive symptoms palliatively in malignant nodules. Standard treatment protocol in symptomatic benign hypoactive thyroid nodules is surgery, if needed LT4 suppression, and radioiodine treatment in certain applications. We applied PLA t...

Thyroid dysfunction is associated with altered levels of several coagulation factors. The aim of this study is to investigate the effect of levothyroxine suppression therapy for benign thyroid nodules on coagulation system.Thirty-six patients with benign thyroid nodules, who were applicant for levothyroxine suppression therapy, were included in the study. Thirty patients completed 1 year follow-up period. Levothyroxine was given to maintain TSH level bet...

Constitutive activation of the cAMP pathway by activating TSHR mutation stimulates both thyrocyte proliferation and function. Thus they lead to formation of toxic thyroid nodules (TTNs) and ultimately hyperthyroidism. The in vitro activity of the various TSH-receptor mutation varies from 2–7 fold cAMP increase over the wild type TSH receptor. One previous study invrestigated a possible genotype to phenotype relation in TTNs with somatic TSHR mutation with a negativ...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome(CS) and is seen in 5 to 10% of patients with endogenous hypercortisolism. The most common types are bronchial carcinoids and small cell lung carcinoma. However, in approximately 10–20% of the cases, overt tumor cannot be found. Here, we described two patients with catastrophic hypercorticolism associated with ectopic CS and who were treated with bilateral adrenale...